PRP vs. PRF vs. PRFM: What’s the Difference and Which Is Right for You?

If you’ve been exploring regenerative treatments in aesthetics, chances are you’ve come across the terms PRP (Platelet-Rich Plasma), PRF (Platelet-Rich Fibrin), and PRFM (Platelet-Rich Fibrin Matrix). While they may sound similar, each has unique properties that make it more or less ideal depending on your skincare or wellness goals.

At Wise Aesthetics, we specialize in advanced regenerative therapies designed to support collagen production, stimulate tissue repair, and enhance your natural beauty—safely and effectively. Here's what you need to know about PRP, PRF, and PRFM.

What Is PRP (Platelet-Rich Plasma)?

PRP is a regenerative treatment made by drawing a small amount of your blood, spinning it in a centrifuge to isolate platelet-rich plasma, and injecting it back into your skin or scalp.

✅ How It Works:

Platelets are rich in growth factors, which stimulate tissue repair, collagen production, and healing. In aesthetic treatments, PRP is often used to improve skin texture, reduce fine lines, and encourage hair regrowth.

🌟 Best Uses for PRP:

• Hair restoration (especially early-stage hair thinning)
• Under-eye rejuvenation
• Microneedling enhancements (aka the “Vampire Facial”)
• Improving skin texture and tone

🔬 Considerations:

• Fast-acting but shorter-lived than PRF
• Requires anticoagulants during processing
• Growth factors are released quickly after injection

What Is PRF (Platelet-Rich Fibrin)?

PRF is considered a second-generation PRP—a more advanced, natural version of PRP. The blood is spun at a slower speed without anticoagulants, allowing more healing cells (like leukocytes and stem cells) and fibrin to remain.

✅ How It Works:

The fibrin in PRF acts like a scaffold, trapping platelets and releasing growth factors slowly over 7–10 days, which extends the regenerative effects of the treatment.

🌟 Best Uses for PRF:

• Under-eye hollows for volume and brightness
• Facial rejuvenation (especially around lips, cheeks, and nasolabial folds)
• Post-microneedling skin repair
• Scar treatment
• Longer-lasting hair restoration

🔬 Considerations:

• No anticoagulants = completely natural
• Slightly thicker consistency = better for structural improvement
• Slower, more sustained release of growth factors

What Is PRFM (Platelet-Rich Fibrin Matrix)?

PRFM is an enhanced version of PRF that’s further processed to form a gel-like matrix. It’s made by adding calcium chloride to the PRF, which activates the fibrin and forms a stable scaffold for growth factors.

✅ How It Works:

PRFM creates a semi-solid matrix that not only delivers growth factors but also provides a mild filler-like effect, making it ideal for targeted facial contouring and volume restoration.

🌟 Best Uses for PRFM:

• Deeper under-eye hollows
• Mild volume loss in the mid-face
• Post-surgical scar refinement
• Complement to dermal fillers for a more natural result

🔬 Considerations:

• More stable and viscous = longer release of growth factors
• Excellent when both regeneration and structural support are desired

Key Differences at a Glance